By Steven Howard,Chris Abell,Harren Jhoti,Martin Drysdale,Daniel A Erlanson,Tony Giannetti,Isabelle Krimm,Michael Hann,Peter Kutchukian,Terry Hughes,Christina Spry,Iwan de Esch,Miles Congreve,Roderick Hubbard,Paul Bamborough
Fragment-based drug discovery is a quickly evolving quarter of study, which has lately noticeable new purposes in parts similar to epigenetics, GPCRs and the identity of novel allosteric binding wallet. the 1st fragment-derived drug used to be lately authorized for the therapy of cancer. it's was hoping that this approval is simply the start of the numerous medicines but to be came across utilizing this attention-grabbing strategy.
This publication is written from a Chemist's viewpoint and comprehensively assesses the impression of fragment-based drug discovery on a wide selection of parts of medicinal chemistry. it is going to end up to be a useful source for medicinal chemists operating in academia and undefined, in addition to somebody attracted to novel drug discovery techniques.
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