By Kim Neve
Functional selectivity refers back to the skill of alternative ligands performing at one receptor subtype to turn on a number of signaling pathways in specific mixtures; that's, one drug may be an agonist at pathway A and an antagonist or partial agonist at pathway B, and one other drug may have the opposite profile. sensible selectivity has profound implications for drug improvement, for chemical biology, and for the layout of experiments to represent receptor functionality. In practical Selectivity of G Protein-Coupled Receptors professional neuroscientists and pharmacologists evaluate the paintings that tested the lifestyles of useful selectivity, positioned it inside a theoretical framework, and supplied a mechanistic foundation for the phenomenon. This fascinating, complete, and future-oriented quantity contains chapters that target theoretical and mechanistic elements of practical selectivity and that lower throughout subfamilies of GPCRs. extra chapters specialize in subfamilies of therapeutically proper receptors the place there's significant proof of ligand sensible selectivity. available and authoritative, practical Selectivity of G Protein-Coupled Receptors is a beneficial academic device and reference resource for college students and scientists attracted to drug improvement, chemical biology, and GPCR functionality.
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